GYKI 12743
GYKI 12743 is a vasoselective, postsynaptic α-adrenoceptor blocker. GYKI 12743 inhibits but does not completely eliminate the cutaneous microcirculatory blood flow reduction evoked by electrical stimulation of the peripheral stump of the cut saphenous nerve in rats. GYKI 12743 can be used for the study of neurological diseases[1].
Product Specifications
CAS Number
[110714-10-8]
UNSPSC
12352005
Target
Adrenergic Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C=CC=N1)N1CCCNCC2OC3=C(C=CC=C3)OC2.Cl
Molecular Formula
C16H20ClN3O3
Molecular Weight
337.80
References & Citations
[1]Pintér E, et al. Noradrenergic and peptidergic sympathetic regulation of cutaneous microcirculation in the rat. Eur J Pharmacol. 1997 Apr 23;325 (1) :57-64.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Curated Selection
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