Onapristone

Onapristone is a progesterone receptor antagonist, with Kds of 11.6 nM and 11.90 nM for human endometrium and myometrium progesterone receptor in saturation analysis. Onapristone has antitumor activity[1][2].

Product Specifications

CAS Number

[96346-61-1]

Product Name Alternative

ZK 98299

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Progesterone Receptor

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Solubility

10 mM in DMSO

Smiles

C[C@]12[C@](CC[C@]2(O)CCCO)([H])[C@@]3([H])C([C@@H](C4=CC=C(N(C)C)C=C4)C1)=C5C(CC3)=CC(CC5)=O

Molecular Formula

C29H39NO3

Molecular Weight

449.62

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Puri CP, et al. Binding characteristics of progesterone and antiprogestin ZK 98.299 in human endometrial and myometrial cytosol. Biochim Biophys Acta. 1989 May 10;1011 (2-3) :176-82.|[2]Huang Y, et al. Inhibiting Nuclear Phospho-Progesterone Receptor Enhances Antitumor Activity of Onapristone in Uterine Cancer. Mol Cancer Ther. 2018 Feb;17 (2) :464-473.