Fadolmidine (hydrochloride)
Fadolmidine hydrochloride is a novel, selective α2-adrenoceptor (α2-AR) agonist with EC50 values of 0.4 nM, 4.9 nM and 0.5 nM for 2A, 2B and 2C, respectively. Fadolmidine hydrochloride has been effective against various submodalities of pain such as heat pain, mechanical pain, and visceral pain. Fadolmidine inhibits also electrically evoked contractions in rat vas deferens[1][2].
Product Specifications
CAS Number
189353-32-0
UNSPSC
12352005
Target
Adrenergic Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
OC1=CC=C2C(C(CC2)CC3=CN=CN3)=C1.Cl
Molecular Formula
C13H15ClN2O
Molecular Weight
250.72
References & Citations
[1]Pertovaara A. Antinociceptive properties of fadolmidine (MPV-2426), a novel alpha2-adrenoceptor agonist. CNS Drug Rev. 2004 Summer;10 (2) :117-26.|[2]Lehtimäki J, et al. In vitro and in vivo profiling of fadolmidine, a novel potent alpha (2) -adrenoceptor agonist with local mode of action. Eur J Pharmacol. 2008 Dec 3;599 (1-3) :65-71.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α adrenergic receptor
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