Fadolmidine (hydrochloride)

Fadolmidine hydrochloride is a novel, selective α2-adrenoceptor (α2-AR) agonist with EC50 values of 0.4 nM, 4.9 nM and 0.5 nM for 2A, 2B and 2C, respectively. Fadolmidine hydrochloride has been effective against various submodalities of pain such as heat pain, mechanical pain, and visceral pain. Fadolmidine inhibits also electrically evoked contractions in rat vas deferens[1][2].

Product Specifications

CAS Number

[189353-32-0]

UNSPSC

12352005

Target

Adrenergic Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

OC1=CC=C2C(C(CC2)CC3=CN=CN3)=C1.Cl

Molecular Formula

C13H15ClN2O

Molecular Weight

250.72

References & Citations

[1]Pertovaara A. Antinociceptive properties of fadolmidine (MPV-2426), a novel alpha2-adrenoceptor agonist. CNS Drug Rev. 2004 Summer;10 (2) :117-26.|[2]Lehtimäki J, et al. In vitro and in vivo profiling of fadolmidine, a novel potent alpha (2) -adrenoceptor agonist with local mode of action. Eur J Pharmacol. 2008 Dec 3;599 (1-3) :65-71.