PRX-03140

PRX-03140 is a selective, blood-brain-barrier permeable 5-HT4 receptor agonist with a Ki value of 110 nM against rat brain 5-HT4 receptor. PRX-03140 can increase cortical ACh and histamine levels. PRX-03140 can be used in the research of Alzheimer's disease[1].

Product Specifications

CAS Number

869493-21-0

Product Name Alternative

VRX-03011 (free base)

UNSPSC

12352005

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(NCCCN1CCCCC1)C=2C(=O)N(C=3SC=CC3C2O)C(C)C

Molecular Formula

C19H27N3O3S

Molecular Weight

377.50

References & Citations

[1]Johnson DE, et al. The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations. J Pharmacol Exp Ther. 2012 Jun;341 (3) :681-91.