Smilagenin (Standard)

Smilagenin (Standard) is the analytical standard of Smilagenin. This product is intended for research and analytical applications. Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases[1]. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1) -receptor density[2]. Smilagenin (SMI) attenuates Aβ (25-35) -induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD[3].

Product Specifications

CAS Number

[126-18-1]

UNSPSC

12352005

Target

Endogenous Metabolite; mAChR; Reference Standards

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

C[C@@H]1[C@@]2(CC[C@@H](C)CO2)O[C@]3([H])[C@@]1([H])[C@@]4([C@@]([C@@]5([H])[C@]([C@@]6([C@](C[C@@H](O)CC6)([H])CC5)C)([H])CC4)([H])C3)C

Molecular Formula

C27H44O3

Molecular Weight

416.64

References & Citations

[1]He X, et al. Smilagenin Protects Dopaminergic Neurons in Chronic MPTP/Probenecid-Lesioned Parkinson's Disease Models. Front Cell Neurosci. 2019 Feb 5;13:18.|[2]Hu Y, et al. Regulation of M1-receptor mRNA stability by smilagenin and its significance in improving memory of aged rats. Neurobiol Aging. 2010 Jun;31 (6) :1010-9.|[3]Zhang R, et al. Smilagenin attenuates beta amyloid (25-35) -induced degeneration of neuronal cells via stimulating the gene expression of brain-derived neurotrophic factor. Neuroscience. 2012 May 17;210:275-85