SB 247083
SB 247083 is a selective, competitive and orally active endothelin-A receptor antagonist with a Ki of 0.41 nM. SB 247083 shows a Ki of 467 nM to endothelin-B receptor. SB 247083 shows a Kb of 3.5 nM for ET-1-induced contraction of rat aorta. SB 247083 can be used for the research of cardiovascular disease[1].
Product Specifications
CAS Number
188186-61-0
UNSPSC
12352005
Target
Endothelin Receptor
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Smiles
COC(C=C1C(OCC1)=C2)=C2C/C(C(O)=O)=C\C3=C(C4=C(C=C(C=C4)Cl)OCC5=C(C=CC=C5)C(O)=O)N(N=C3)CCCC
Molecular Formula
C34H33ClN2O7
Molecular Weight
617.09
References & Citations
[1]Douglas SA, et al. Pharmacologic characterization of the novel, orally available endothelin-A--selective antagonist SB 247083. J Cardiovasc Pharmacol. 1998;31 Suppl 1:S273-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ETA; ETB
Frequently Asked Questions
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