Sergolexole (maleate)

Sergolexole maleate is a potent 5-HT2 receptor antagonist. Sergolexole maleate antagonizes serotonin-amplified platelet aggregation[1][2].

Product Specifications

CAS Number

[108674-87-9]

UNSPSC

12352005

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cardiovascular Disease

Smiles

OC(/C=C\C(O)=O)=O.CC(N1C2=C3C([C@]4([H])[C@@](N(C[C@@H](C4)C(O[C@@H]5CC[C@H](CC5)OC)=O)C)([H])CC3=C1)=CC=C2)C

Molecular Formula

C30H40N2O7

Molecular Weight

540.65

References & Citations

[1]Cohen ML, et al. 5-Hydroxytryptamine2 receptor antagonist activity of the acid metabolite (1-isopropyl dihydrolysergic acid) of the ergoline ester, sergolexole (LY281067) . J Pharmacol Exp Ther. 1989 Dec;251 (3) :1006-11.|[2]McBride PA, et al. Inhibition of serotonin-amplified human platelet aggregation by ketanserin, ritanserin, and the ergoline 5HT2 receptor antagonists-LY53857, sergolexole, and LY237733. Life Sci. 1990;47 (23) :2089-95.