ME-1228

ME-1228 is an antibacterial agent and sulfur-containing analogue of OCP 9-176. ME 1228 is generally twofold more active than OCP 9-176 against Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Providencia stuartii, Proteus vulgaris, and Serratia marcescens. ME-1228 has antibacterial activity against E. coli UB 1005, P. aeruginosa K779K, and P. aeruginosa E4, with MICs of 0.25, 0.25, and 1 μg/mL, respectively[1].

Product Specifications

CAS Number

[115369-52-3]

UNSPSC

12352005

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

[O-]C(C1=C(CSC2=CC=[N+](CC)C=C2)CS[C@@]([C@@H]3NC(/C(C4=CSC(N)=N4)=N\O[C@@H](C)C(O)=O)=O)([H])N1C3=O)=O

Molecular Formula

C23H24N6O7S3

Molecular Weight

592.67

References & Citations

[1]Gu JW, et al. In vitro activity of an oxycephem OCP 9-176 compared with its sulfur analog and other beta-lactams. Diagn Microbiol Infect Dis. 1991 Mar-Apr;14 (2) :135-40.