ICI-200880
ICI-200880 is a potent, selective and reversible human neutrophil elastase (HNE) inhibitor. ICI-200880 is promising for research of inflammatory lung diseases related to neutrophil elastase, such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) [1].
Product Specifications
CAS Number
105080-50-0
UNSPSC
12352005
Target
Elastase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CC=C(C(NS(=O)(C2=CC=C(Cl)C=C2)=O)=O)C=C1)N[C@@H](C(C)C)C(N3[C@@H](CCC3)C(NC(C(C)C)C(C(F)(F)F)=O)=O)=O
Molecular Formula
C30H34ClF3N4O7S
Molecular Weight
687.13
References & Citations
[1]Davis PC, et al. A specific radioimmunoassay for the measurement of ICI 200,880, an elastase inhibitor, in human serum. J Pharm Biomed Anal. 1993 Jul;11 (7) :549-56.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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