PF-00446687 (hydrochloride)

PF-00446687 hydrochloride is a potent, brain-penetrating, selective melanocortin 4 receptor (MC4R) agonist with an EC50 of 12 nM. PF-00446687 hydrochloride can be used in the research of sexual dysfunction[1][2].

Product Specifications

CAS Number

[862282-10-8]

UNSPSC

12352005

Target

Melanocortin Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Endocrinology

Smiles

O=C(N1C[C@H]([C@@]([C@H](C1)C)(C2=CC=CC=C2)O)C)[C@H]3[C@H](C4=C(C=C(C=C4)F)F)CN(C3)C(C)(C)C.Cl

Molecular Formula

C28H37ClF2N2O2

Molecular Weight

507.06

References & Citations

[1]Lansdell MI, et al. Discovery of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans. J Med Chem. 2010 Apr 22;53 (8) :3183-97. |[2]Modi ME, et al. Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole. Neuropsychopharmacology. 2015 Jul;40 (8) :1856-65.