Crinecerfont (tosylate)

Crinecerfont tosylate (SSR-125543 tosylate) hydrochloride is a potent, orally active, non-peptide CRF1 receptor antagonist. Crinecerfont tosylate can be used for Classic congenital adrenal hyperplasia (CAH) research[1]. Crinecerfont tosylate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2649012-17-7]

Product Name Alternative

SSR-125543 (tosylate)

UNSPSC

12352005

Target

CFTR

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

C#CCN(C1=NC(C2=C(C=C(C(C)=C2)OC)Cl)=C(S1)C)[C@H](C3=CC(F)=C(C=C3)C)CC4CC4.O=S(C5=CC=C(C)C=C5)(O)=O

Molecular Formula

C34H36ClFN2O4S2

Molecular Weight

655.24

References & Citations

[1]Newfield R S, et al. Crinecerfont, a CRF1 receptor antagonist, lowers adrenal androgens in adolescents with congenital adrenal hyperplasia[J]. The Journal of Clinical Endocrinology & Metabolism, 2023, 108 (11) : 2871-2878.