Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Rucaparib (phosphate) (Standard)

Rucaparib (phosphate) (Standard) is the analytical standard of Rucaparib (phosphate) . This product is intended for research and analytical applications. Rucaparib (AG014699) phosphate is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a Ki of 1.4 nM for PARP1. Rucaparib phosphate is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib phosphate has the potential for castration-resistant prostate cancer (CRPC) research[1][2][3][4].

Product Specifications

CAS Number

459868-92-9

Product Name Alternative

AG-014699 (phosphate) (Standard) ; PF-01367338 (phosphate) (Standard)

UNSPSC

12352005

Target

PARP; Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Others

Field of Research

Cancer

Smiles

O=P(O)(O)O.FC1=CC2=C3C(CCNC2=O)=C(C4=CC=C(CNC)C=C4)NC3=C1

Molecular Formula

C19H21FN3O5P

Molecular Weight

421.36

References & Citations

[1]Thomas HD, et al. Preclinical selection of a novel poly (ADP-ribose) polymerase inhibitor for clinical trial. Mol Cancer Ther, 2007, 6 (3), 945-956.|[2]Hunter JE, et al. NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699. Oncogene, 2012, 31 (2), 251-264.|[3]Daniel RA, et al. Inhibition of poly (ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma. Clin Cancer Res, 2009, 15 (4), 1241-1249.|[4]Matt Shirley, et al. Rucaparib: A Review in Ovarian Cancer. Target Oncol. 2019 Apr;14 (2) :237-246.|[5]Jianneng Li, et al. Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation. Sci Transl Med. 2021 May 26;13 (595) :eabe8226.|[6]J Murray, et al. Tumour cell retention of rucaparib, sustained PARP inhibition and efficacy of weekly as well as daily schedules. Br J Cancer. 2014 Apr 15;110 (8) :1977-84.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

APEX1 Antibody
8C10493-AAT 50 µg

APEX1 Antibody

Sign In for Pricing
View Details
Human USP37 activation kit by CRISPRa
GA111690 1 Kit

Human USP37 activation kit by CRISPRa

Sign In for Pricing
View Details
Isotype Control, Mouse IgG1 Kappa (IGG1/1331), CF594 Conjugate, 0.1 mg/mL
BNC941331-1ML 1x 1 mL

Isotype Control, Mouse IgG1 Kappa (IGG1/1331), CF594 Conjugate, 0.1 mg/mL

Sign In for Pricing
View Details
Human DCP1A activation kit by CRISPRa
GA110982 1 Kit

Human DCP1A activation kit by CRISPRa

Sign In for Pricing
View Details
6030468B19Rik Mouse Gene Knockout Kit (CRISPR)
KN500482 1 Kit

6030468B19Rik Mouse Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
4-(2-Chloroethyl)morpholine Hydrochloride
TRC-C366195-10G 10 g

4-(2-Chloroethyl)morpholine Hydrochloride

Sign In for Pricing
View Details