BMS-184476
BMS-184476 is a selective microtubule inhibitor with potent antitumor activity. BMS-184476 induces G2/M phase arrest and promotes tumor cell apoptosis. BMS-184476 is promising for research of solid tumors, such as non-small cell lung cancer[1].
Product Specifications
CAS Number
160237-25-2
UNSPSC
12352005
Target
Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC(O[C@]12[C@]([C@@H]3OC(C4=CC=CC=C4)=O)([H])[C@@]([C@@H](OCSC)C[C@@]1([H])OC2)(C([C@@H](C5=C(C)[C@@H](OC([C@H](O)[C@H](C6=CC=CC=C6)NC(C7=CC=CC=C7)=O)=O)C[C@]3(O)C5(C)C)OC(C)=O)=O)C)=O
Molecular Formula
C49H55NO14S
Molecular Weight
914.02
References & Citations
[1]Kim JS, et al. The novel taxane analogs, BMS-184476 and BMS-188797, potentiate the effects of radiation therapy in vitro and in vivo against human lung cancer cells. Int J Radiat Oncol Biol Phys. 2001 Oct 1;51 (2) :525-34.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC041820-100 1x 100 µL
Ep-CAM / CD326 (Epithelial Marker) (rVU-1D9), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740391-500 1x 500 µL
CD81 / TAPA-1 (1.3.3.22), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC880266-100 1x 100 µL
Human IgG Immunoglobulin (IG266), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740009-100 1x 100 µL
MART-1 / Melan-A (M2-7C10), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680009-500 1x 500 µL
MART-1 / Melan-A (M2-7C10), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC401870-100 1x 100 µL
CD10 (Membrane Metalloendopeptidase) (MME/1870), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details