BMS-184476

BMS-184476 is a selective microtubule inhibitor with potent antitumor activity. BMS-184476 induces G2/M phase arrest and promotes tumor cell apoptosis. BMS-184476 is promising for research of solid tumors, such as non-small cell lung cancer[1].

Product Specifications

CAS Number

[160237-25-2]

UNSPSC

12352005

Target

Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC(O[C@]12[C@]([C@@H]3OC(C4=CC=CC=C4)=O)([H])[C@@]([C@@H](OCSC)C[C@@]1([H])OC2)(C([C@@H](C5=C(C)[C@@H](OC([C@H](O)[C@H](C6=CC=CC=C6)NC(C7=CC=CC=C7)=O)=O)C[C@]3(O)C5(C)C)OC(C)=O)=O)C)=O

Molecular Formula

C49H55NO14S

Molecular Weight

914.02

References & Citations

[1]Kim JS, et al. The novel taxane analogs, BMS-184476 and BMS-188797, potentiate the effects of radiation therapy in vitro and in vivo against human lung cancer cells. Int J Radiat Oncol Biol Phys. 2001 Oct 1;51 (2) :525-34.