α-Epibromide
α-Epibromide (16α-Bromoepiandrosterone) is an adrenal steroid derivative. α-Epibromide decreases nitric oxide production. α-Epibromide restores T helper cell type 1 activity and accelerates chemotherapy-induced bacterial clearance in a model of progressive pulmonary tuberculosis. α-Epibromide reduces mortality related to excessive inflammation and opportunistic lung infections[1][2].
Product Specifications
CAS Number
28507-02-0
Product Name Alternative
16α-Bromoepiandrosterone
UNSPSC
12352211
Target
Drug Derivative; NO Synthase
Related Pathways
Immunology/Inflammation; Others
Field of Research
Infection; Inflammation/Immunology
Smiles
C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H](CC2)O)([H])[C@@]4([H])[C@](CC3)(C([C@@H](C4)Br)=O)C
Molecular Formula
C19H29BrO2
Molecular Weight
369.34
References & Citations
[1]Hernández-Pando R, et al. 16alpha-Bromoepiandrosterone restores T helper cell type 1 activity and accelerates chemotherapy-induced bacterial clearance in a model of progressive pulmonary tuberculosis. J Infect Dis. 2005 Jan 15;191 (2) :299-306.|[2]Nicoletti F, et al. 16alpha-Bromoepiandrosterone (HE2000) limits non-productive inflammation and stimulates immunity in lungs. Clin Exp Immunol. 2009 Dec;158 (3) :308-16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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