α-Epibromide

α-Epibromide (16α-Bromoepiandrosterone) is an adrenal steroid derivative. α-Epibromide decreases nitric oxide production. α-Epibromide restores T helper cell type 1 activity and accelerates chemotherapy-induced bacterial clearance in a model of progressive pulmonary tuberculosis. α-Epibromide reduces mortality related to excessive inflammation and opportunistic lung infections[1][2].

Product Specifications

CAS Number

[28507-02-0]

Product Name Alternative

16α-Bromoepiandrosterone

UNSPSC

12352211

Target

Drug Derivative; NO Synthase

Related Pathways

Immunology/Inflammation; Others

Field of Research

Infection; Inflammation/Immunology

Smiles

C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H](CC2)O)([H])[C@@]4([H])[C@](CC3)(C([C@@H](C4)Br)=O)C

Molecular Formula

C19H29BrO2

Molecular Weight

369.34

References & Citations

[1]Hernández-Pando R, et al. 16alpha-Bromoepiandrosterone restores T helper cell type 1 activity and accelerates chemotherapy-induced bacterial clearance in a model of progressive pulmonary tuberculosis. J Infect Dis. 2005 Jan 15;191 (2) :299-306.|[2]Nicoletti F, et al. 16alpha-Bromoepiandrosterone (HE2000) limits non-productive inflammation and stimulates immunity in lungs. Clin Exp Immunol. 2009 Dec;158 (3) :308-16.