ONO-1714
ONO-1714 is an orally active nitric oxide synthase inhibitor. ONO-1714 attenuates endotoxin-induced acute lung injury, reduces intestinal ischemia–reperfusion injury, represses biliary carcinogenesis[1][2][3].
Product Specifications
CAS Number
214479-33-1
UNSPSC
12352005
Target
NO Synthase
Related Pathways
Immunology/Inflammation
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Smiles
Cl[C@@H]1[C@@]2([H])[C@]1([H])N=C(C[C@@H]2C)N.Cl
Molecular Formula
C7H12Cl2N2
Molecular Weight
195.09
References & Citations
[1]Mishima T, et al. Chemopreventative effect of an inducible nitric oxide synthase inhibitor, ONO-1714, on inflammation-associated biliary carcinogenesis in hamsters. Carcinogenesis. 2009 Oct;30 (10) :1763-7.|[2]Naito Y, et al. A novel potent inhibitor of inducible nitric oxide inhibitor, ONO-1714, reduces intestinal ischemia-reperfusion injury in rats. Nitric Oxide. 2004 May;10 (3) :170-7. |[3]Mikawa K, et al. ONO-1714, a nitric oxide synthase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits. Anesth Analg. 2003 Dec;97 (6) :1751-1755.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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