ONO-1714

ONO-1714 is an orally active nitric oxide synthase inhibitor. ONO-1714 attenuates endotoxin-induced acute lung injury, reduces intestinal ischemia–reperfusion injury, represses biliary carcinogenesis[1][2][3].

Product Specifications

CAS Number

[214479-33-1]

UNSPSC

12352005

Target

NO Synthase

Related Pathways

Immunology/Inflammation

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Smiles

Cl[C@@H]1[C@@]2([H])[C@]1([H])N=C(C[C@@H]2C)N.Cl

Molecular Formula

C7H12Cl2N2

Molecular Weight

195.09

References & Citations

[1]Mishima T, et al. Chemopreventative effect of an inducible nitric oxide synthase inhibitor, ONO-1714, on inflammation-associated biliary carcinogenesis in hamsters. Carcinogenesis. 2009 Oct;30 (10) :1763-7.|[2]Naito Y, et al. A novel potent inhibitor of inducible nitric oxide inhibitor, ONO-1714, reduces intestinal ischemia-reperfusion injury in rats. Nitric Oxide. 2004 May;10 (3) :170-7. |[3]Mikawa K, et al. ONO-1714, a nitric oxide synthase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits. Anesth Analg. 2003 Dec;97 (6) :1751-1755.