DTS-201
DTS-201 (CPI-0004) is a peptidic prodrug of Doxorubicin. DTS-201, comprising the tetrapeptide portion, is cleaved by endopeptidases in the tumor environment to produce metabolites that subsequently enter the cell and are converted to active Doxorubicin. DTS-201 shows antitumoral efficacy in tumor xenograft models of prostate, breast, and lung cancer[1].
Product Specifications
CAS Number
274912-87-7
UNSPSC
12352005
Target
Aminopeptidase; Peptide-Drug Conjugates (PDCs)
Related Pathways
Antibody-drug Conjugate/ADC Related; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
OC(CCC(NCCC(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@H]([C@H](O)[C@H](C)O1)C[C@]1([H])O[C@@H]2C3=C(C[C@](C(CO)=O)(O)C2)C(O)=C4C(C(C5=C(OC)C=CC=C5C4=O)=O)=C3O)=O)=O)=O)=O)=O)=O
Molecular Formula
C49H65N5O18
Molecular Weight
1012.06
References & Citations
[1]Ravel D, et al. Preclinical toxicity, toxicokinetics, and antitumoral efficacy studies of DTS-201, a tumor-selective peptidic prodrug of doxorubicin. Clinical cancer research : an official journal of the American Association for Cancer Research. 2008, 14 (4), 1258–1265.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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