E-5842 (citrate)

E-5842 citrate is a σ receptor ligand (Ki: 4 nM for σ1 receptor) . E-5842 citrate increases levels of Fos in the medial prefrontal cortex and the nucleus accumbens, without affecting the levels of the protein in the striatum. E-5842 citrate can be used in the research of psychiatric disorders[1].

Product Specifications

CAS Number

[220120-14-9]

UNSPSC

12352005

Target

Sigma Receptor

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

FC1=CC=C(C=C1)C2=CCN(CC2)CCCCN3N=CN=C3.O=C(O)CC(O)(CC(O)=O)C(O)=O

Molecular Formula

C23H29FN4O7

Molecular Weight

492.50

References & Citations

[1]Guitart X, et al. The effect of E-5842, a sigma receptor ligand and potential atypical antipsychotic, on Fos expression in rat forebrain. Eur J Pharmacol. 1998 Dec 18;363 (2-3) :127-30.