Eniporide (mesylate)
Eniporide mesylate (EMD 96785 mesylate) is a Na (+) /H (+) exchange (NHE) inhibitor. Eniporide mesylate specifically inhibits the NHE-1 isoform. Eniporide mesylate improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide mesylate regulates cardiac performance and high-energy phosphate content[1][2].
Product Specifications
CAS Number
190368-98-0
UNSPSC
12352005
Target
Na+/H+ Exchanger (NHE)
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C(C1=C(C)C=C(N2C=CC=C2)C(S(=O)(C)=O)=C1)NC(N)=N.O=S(O)(C)=O
Molecular Formula
C15H20N4O6S2
Molecular Weight
416.47
References & Citations
[1]Zeymer U, et al. The Na (+) /H (+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial. J Am Coll Cardiol. 2001 Nov 15;38 (6) :1644-50. |[2]Klass O, et al. Effect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest. Ann Thorac Surg. 2004 Feb;77 (2) :658-63.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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