Eniporide (mesylate)

Eniporide mesylate (EMD 96785 mesylate) is a Na (+) /H (+) exchange (NHE) inhibitor. Eniporide mesylate specifically inhibits the NHE-1 isoform. Eniporide mesylate improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide mesylate regulates cardiac performance and high-energy phosphate content[1][2].

Product Specifications

CAS Number

[190368-98-0]

UNSPSC

12352005

Target

Na+/H+ Exchanger (NHE)

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

O=C(C1=C(C)C=C(N2C=CC=C2)C(S(=O)(C)=O)=C1)NC(N)=N.O=S(O)(C)=O

Molecular Formula

C15H20N4O6S2

Molecular Weight

416.47

References & Citations

[1]Zeymer U, et al. The Na (+) /H (+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial. J Am Coll Cardiol. 2001 Nov 15;38 (6) :1644-50. |[2]Klass O, et al. Effect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest. Ann Thorac Surg. 2004 Feb;77 (2) :658-63.