RSD-921

RSD-921 (PD-123497) is a potent Na+ channel blocker with anti-arrhythmic activity. RSD-921 displays a low affinity for κ-opioid receptors and behaves as a weak κ-agonist in vitro. RSD 921 displays state-, time- and voltage-dependent block of the open state of cardiac, skeletal muscle and neuronal Na+ channels expressed in Xenopus oocytes. RSD-921 can be used for cardiac arrhythmias research[1][2].

Product Specifications

CAS Number

[114419-77-1]

Product Name Alternative

PD-123497

UNSPSC

12352005

Target

Opioid Receptor; Sodium Channel

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Cardiovascular Disease

Smiles

O=C(N(C)[C@H]1[C@H](N2CCCC2)CCCC1)CC3=C(C=CS4)C4=CC=C3

Molecular Formula

C21H28N2OS

Molecular Weight

356.52

References & Citations

[1]Meecham KG, et al. An in vitro profile of activity for the (+) and (-) enantiomers of spiradoline and PD117302. Eur J Pharmacol. 1989 Dec 7;173 (2-3) :151-7.|[2]Pugsley MK, et al. Molecular analysis of the Na+ channel blocking actions of the novel class I anti-arrhythmic agent RSD 921. Br J Pharmacol. 1999 May;127 (1) :9-18.