NK-611
NK-611 (VP 19) is an epipodophyllotoxin derivative. NK-611 induces DNA double-strand breaks by inhibiting topoisomerase II (IC50 = 56 μM). NK-611 does not inhibit microtubule polymerization, thus avoiding the side effects of the parent compound, Podofilox. NK-611 exhibits broad-spectrum antitumor activity and demonstrates potent efficacy in in vivo models of leukemia. NK-611 can be used in cancer research[1][2].
Product Specifications
CAS Number
105655-99-0
Product Name Alternative
VP 19
UNSPSC
12352005
Target
DNA/RNA Synthesis; Topoisomerase
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1[C@]2([H])[C@H](C3=CC(OC)=C(O)C(OC)=C3)C4=CC(OCO5)=C5C=C4[C@@H](O[C@@]6([H])[C@@H]([C@H]([C@@]7([H])[C@](CO[C@@H](C)O7)([H])O6)O)N(C)C)[C@@]2([H])CO1
Molecular Formula
C31H37NO12
Molecular Weight
615.62
References & Citations
[1]Daley L, et al. Synthesis and antitumor activity of new glycosides of epipodophyllotoxin, analogues of etoposide, and NK 611. J Med Chem. 1998 Nov 5;41 (23) :4475-85. |[2]Hanauske AR, et al. Activity of NK 611, a new epipodophyllotoxin derivative, against colony forming units from freshly explanted human tumours in vitro. Eur J Cancer. 1995 Sep;31A (10) :1677-81.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
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