FK 973
FK 973 is a dihydrobenzoxazine anticancer agent. FK 973 selectively inhibits DNA synthesis and can form DNA cross-links through cytoplasmic activation. FK 973 exhibits significant antitumor activity in various animal tumor models and human tumor xenografts, with relatively weak myelosuppressive effects. FK 973 is sensitive to neural tumor cells. FK 973 can be used for DNA-targeted antitumor research[1][2].
Product Specifications
CAS Number
[114580-45-9]
UNSPSC
12352005
Target
DNA Alkylator/Crosslinker; DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
CC(O[C@]12[C@@H]3[C@H](C[N@@](C4=CC(C=O)=CC(OC(C)=O)=C4[C@@H]2COC(N)=O)O1)N3C(C)=O)=O
Molecular Formula
C20H21N3O9
Molecular Weight
447.40
References & Citations
[1]Shimizu K, et al. [Antitumor efficacy of FK 973 on malignant glioma cells]. Gan To Kagaku Ryoho. 1989 Jul;16 (7) :2367-72. Japanese.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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