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Roxindole (hydrochloride) (Standard)

Roxindole (hydrochloride) (Standard) is the analytical standard of Roxindole (hydrochloride) . This product is intended for research and analytical applications. Roxindole hydrochloride (EMD 38362), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM) . Antipsychotic and antidepressant activities[1][2][3].

Product Specifications

CAS Number

108050-82-4

Product Name Alternative

EMD 38362 (Standard)

UNSPSC

12352005

Target

Dopamine Receptor; Reference Standards; Serotonin Transporter

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

OC1=CC2=C(C=C1)NC=C2CCCCN3CCC(C4=CC=CC=C4)=CC3.[H]Cl

Molecular Formula

C23H27ClN2O

Molecular Weight

382.93

References & Citations

[1]Bartoszyk GD, Harting J, Minck KO. Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. J Pharmacol Exp Ther. 1996;276 (1) :41-48.|[2]Wetzel H, et al. Roxindole, a dopamine autoreceptor agonist, in the treatment of positive and negative schizophrenic symptoms. Am J Psychiatry. 1994;151 (10) :1499-1502.|[3]Maj J, et al. Roxindole, a dopamine autoreceptor agonist with a potential antidepressant activity. II. Effects on the 5-hydroxytryptamine system. Pharmacopsychiatry. 1997;30 (2) :55-61.|[4]Prehn JH, et al. Effects of serotonergic drugs in experimental brain ischemia: evidence for a protective role of serotonin in cerebral ischemia. Brain Res. 1993;630 (1-2) :10-20.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Isoform

5-HT1 Receptor

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