Losoxantrone (hydrochloride)

Losoxantrone hydrochloride (CI 941 hydrochloride) is a DNA-binding agent. Losoxantrone hydrochloride has broad-spectrum antitumour activity. Losoxantrone hydrochloride induces dose-dependent leukopenia[1].

Product Specifications

CAS Number

[88303-61-1]

Product Name Alternative

CI 941 (hydrochloride) ; DUP 94 (hydrochloride)

UNSPSC

12352005

Target

DNA Alkylator/Crosslinker

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

OCCNCCNC1=C2C3=C(C=C1)N(CCNCCO)N=C3C4=C(C(O)=CC=C4)C2=O.Cl.Cl

Molecular Formula

C22H29Cl2N5O4

Molecular Weight

498.40

References & Citations

[1]Graham MA, et al. The pharmacokinetics and toxicity of the anthrapyrazole anti-cancer drug CI-941 in the mouse: a guide for rational dose escalation in patients. Cancer Chemother Pharmacol. 1989;23 (1) :8-14.