Teloxantrone
Teloxantrone (CI-937; DUP 937) is a DNA synthesis inhibitor (IC50: 0.33 μM) . Teloxantrone has antitumor activity and can be used in colorectal cancer research[1][2].
Product Specifications
CAS Number
91441-48-4
Product Name Alternative
CI-937; DUP 937
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
CNCCNC1=C2C3=C(C=C1)N(CCNCCO)N=C3C4=C(C(O)=CC=C4O)C2=O
Molecular Formula
C21H25N5O4
Molecular Weight
411.45
References & Citations
[1]Fry DW, et al. In vitro DNA strand scission and inhibition of nucleic acid synthesis in L1210 leukemia cells by a new class of DNA complexers, the anthra[1,9-cd]pyrazol-6 (2H) -ones (anthrapyrazoles) . Biochem Pharmacol. 1985 Oct 1;34 (19) :3499-508.|[2]Maroun JA, et al. Phase II study on DuP 937 (Teloxantrone) in colorectal carcinoma. A Canadian National Cancer Institute Clinical Trial Group study. Invest New Drugs. 1993 May-Aug;11 (2-3) :235-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
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