Pazelliptine

Pazelliptine (Pazellipticine) is a DNA topoisomerase inhibitor and antitumour agent[1][2].

Product Specifications

CAS Number

[65222-35-7]

Product Name Alternative

Pazellipticine; BD-40

UNSPSC

12352005

Target

Topoisomerase

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CCN(CC)CCCNC1=NC=CC2=C1C=C3C4=CN=CC=C4NC3=C2C

Molecular Formula

C22H27N5

Molecular Weight

361.48

References & Citations

[1]Balosso J, et al. Additive and supraadditive interaction between ionizing radiation and pazelliptine, a DNA topoisomerase inhibitor, in Chinese hamster V-79 fibroblasts. Cancer Res. 1991 Jun 15;51 (12) :3204-11. |[2]Fontaine-Aupart M P, et al. Proton and charge transfer in the intercalating antitumour drug pazelliptine. Journal of the Chemical Society, Perkin Transactions 2, 1996 (8) : 1767-1774.