Tezacitabine (hydrate)
Tezacitabine hydrate is a cytostatic and cytotoxic antimetabolite and nucleoside analogue. Tezacitabine hydrate irreversibly inhibits the ribonucleotide reductase and interferes with DNA replication and repair. Tezacitabine hydrate effectively induces cells Apoptosis. Tezacitabine hydrate has the potential for leukemias and solid tumors (carcinomas) treatment[1][2].
Product Specifications
CAS Number
171176-43-5
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O[C@H]([C@@H](CO)O[C@H]/1N2C(N=C(C=C2)N)=O)C1=C/F.O
Molecular Formula
C10H14FN3O5
Molecular Weight
275.23
References & Citations
[1]Janusz S Skierski, et al. Tezacitabine Blocks Tumor Cells in G1 and S Phases of the Cell Cycle and Induces Apoptotic Cell Death. Acta Pol Pharm. May-Jun 2005;62 (3) :195-205.|[2]Pietro Taverna, et al. Tezacitabine Enhances the DNA-directed Effects of Fluoropyrimidines in Human Colon Cancer Cells and Tumor Xenografts. Biochem Pharmacol. 2007 Jan 1;73 (1) :44-55.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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