Clemeprol

Clemeprol (BRL 14342) is an orally active Noradrenaline (NA) and 5-HT uptake blocker. Clemeprol inhibits 6- Hydroxydopamine (HY-B1081) -induced depletion of brain NA. Clemeprol exerts a dose-dependent inhibition of Reserpine (HY-N0480) -induced hypothermia. Clemeprol can be used in the research of depression[1][2].

Product Specifications

CAS Number

[71827-56-0]

Product Name Alternative

BRL 14342

UNSPSC

12352005

Target

Serotonin Transporter

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

CN(C)CC(O)C(C1=CC=CC=C1)C2=CC(Cl)=CC=C2

Molecular Formula

C17H20ClNO

Molecular Weight

289.80

References & Citations

[1]Clark JA, et al. Substituted 3-amino-1,1-diaryl-2-propanols as potential antidepressant agents. J Med Chem. 1979 Nov;22 (11) :1373-9.|[2]Clark MS, et al. Pharmacological and biochemical properties of BRL 14342, a novel potential antidepressant drug. Neuropharmacology. 1980 Dec;19 (12) :1207-8.