L-652343
L-652343 is a dual cyclooxygenase/lipoxygenase inhibitor. L-652343 can inhibit the production of LTB4 in isolated human polymorphonuclear leukocytes treated with Calcimycin (IC50: 1.4 μM), but it is inactive in whole blood. L-652343 can be used in the research of inflammatory and immune diseases[1].
Product Specifications
CAS Number
107008-29-7
UNSPSC
12352005
Target
COX; Leukotriene Receptor; Lipoxygenase
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
OC1=C(C(N/C=C(C2=CC=CC=C2)/C3=CC=CS3)=O)SC4=C1C=C(C(F)(F)F)C=C4
Molecular Formula
C22H14F3NO2S2
Molecular Weight
445.48
References & Citations
[1]Gresele P, et al. L-652,343, a novel dual cyclo/lipoxygenase inhibitor, inhibits LTB4-production by stimulated human polymorphonuclear cells but not by stimulated human whole blood. Biochem Pharmacol. 1987 Oct 15;36 (20) :3529-31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LTB4
Frequently Asked Questions
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