OCA 983

OCA 983 is an orally active tetrahydrofuranyl 1β-methylcarbapenem antibiotic. OCA 983 exhibits potent inhibitory activity against class A and class C β-lactamases. OCA 983 possesses a broad antibacterial spectrum, and can be used in the research of infectious diseases[1][2][3].

Product Specifications

CAS Number

161856-02-6

UNSPSC

12352005

Target

Antibiotic; Bacterial; Beta-lactamase

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

OC(C1=C(S[C@H]2[C@H](OCC2)CNC([C@@H](N)C(C)C)=O)[C@H](C)[C@@]([C@@]3([H])[C@H](O)C)([H])N1C3=O)=O

Molecular Formula

C20H31N3O6S

Molecular Weight

441.54

References & Citations

[1]Jiraskova N. THF carbapenems. Wyeth Ayerst. Curr Opin Investig Drugs. 2001 Aug;2 (8) :1035-8.|[2]Bitha P, et al. Convergent syntheses of oral THF 1beta-methylcarbapenems. J Antibiot (Tokyo) . 1999 Jul;52 (7) :643-8.|[3]Bronson JJ, et al. Quinolone, everninomycin, glycylcycline, carbapenem, lipopeptide and cephem antibacterials in clinical development. Curr Med Chem. 2001 Dec;8 (14) :1775-93.