TWS119 (Standard)
TWS119 (Standard) is the analytical standard of TWS119. This product is intended for research and analytical applications. TWS119 is a specific inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway.
Product Specifications
CAS Number
[601514-19-6]
UNSPSC
12352005
Target
Autophagy; GSK-3; Reference Standards; Wnt
Related Pathways
Autophagy; Others; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Neurological Disease; Cancer
Smiles
OC1=CC=CC(OC2=C3C(NC(C4=CC=CC(N)=C4)=C3)=NC=N2)=C1
Molecular Formula
C18H14N4O2
Molecular Weight
318.33
References & Citations
[1]Wang W, et al. GSK-3β inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats. Mol Neurobiol. 2016 Dec;53 (10) :7028-7036. Epub 2015 Dec 15.|[2]Chen YQ, et al. Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human γδT cells against colon cancer. Exp Cell Res. 2017 Nov 16. pii: S0014-4827 (17) 30587-6.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Curated Selection
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