TWS119 (Standard)

TWS119 (Standard) is the analytical standard of TWS119. This product is intended for research and analytical applications. TWS119 is a specific inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway.

Product Specifications

CAS Number

[601514-19-6]

UNSPSC

12352005

Target

Autophagy; GSK-3; Reference Standards; Wnt

Related Pathways

Autophagy; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Neurological Disease; Cancer

Smiles

OC1=CC=CC(OC2=C3C(NC(C4=CC=CC(N)=C4)=C3)=NC=N2)=C1

Molecular Formula

C18H14N4O2

Molecular Weight

318.33

References & Citations

[1]Wang W, et al. GSK-3β inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats. Mol Neurobiol. 2016 Dec;53 (10) :7028-7036. Epub 2015 Dec 15.|[2]Chen YQ, et al. Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human γδT cells against colon cancer. Exp Cell Res. 2017 Nov 16. pii: S0014-4827 (17) 30587-6.