Sulfatroxazole-d4

Sulfatroxazole-d4 (Isosulfafurazole-d4) is the deuterium labeled Sulfatroxazole (HY-105829) [1]. Sulfatroxazole (Isosulfafurazole) (compound 12) is a selective antagonist of ETA receptor (IC50 of 0.26 μM) [2].

Product Specifications

Product Name Alternative

Isosulfafurazole-d4

UNSPSC

12352005

Target

Endothelin Receptor; Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Others

Field of Research

Metabolic Disease

Solubility

10 mM in DMSO

Smiles

O=S(C1=C([2H])C([2H])=C(N)C([2H])=C1[2H])(NC2=NOC(C)=C2C)=O

Molecular Formula

C11H9D4N3O3S

Molecular Weight

271.33

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Stein P D, et al. Discovery and structure-activity relationships of sulfonamide ETA-selective antagonists[J]. Journal of medicinal chemistry, 1995, 38 (8) : 1344-1354.