Kalafungin

Kalafungin is an antibiotic, antimicrobial agent and a β-lactamase inhibitor from marine Streptomyces, with IC50 of 225.37 μM. Kalafungin destroys cell membranes. Kalafungin shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria (such as S. aureus ATCC 33591 and S. aureus ATCC 23591), and, to a lesser extent, gram-negative bacteria[1][2].

Product Specifications

CAS Number

[11048-15-0]

Product Name Alternative

Kalamycin; U-19718

UNSPSC

12352005

Target

Antibiotic; Bacterial; Beta-lactamase; Fungal

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C1C2=C([C@H](O[C@@](C3)([H])[C@]2([H])OC3=O)C)C(C4=C(O)C=CC=C14)=O

Molecular Formula

C16H12O6

Molecular Weight

300.26

References & Citations

[1]Jabila Mary TR, et al. β-lactamase inhibitory potential of kalafungin from marine Streptomyces in Staphylococcus aureus infected zebrafish. Microbiol Res. 2021 Mar;244:126666. |[2]Johnson LE, et al. Kalafungin, a new antibiotic produced by Streptomyces tanashiensis strain Kala. Appl Microbiol. 1968 Dec;16 (12) :1815-21.