Kalafungin
Kalafungin is an antibiotic, antimicrobial agent and a β-lactamase inhibitor from marine Streptomyces, with IC50 of 225.37 μM. Kalafungin destroys cell membranes. Kalafungin shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria (such as S. aureus ATCC 33591 and S. aureus ATCC 23591), and, to a lesser extent, gram-negative bacteria[1][2].
Product Specifications
CAS Number
11048-15-0
Product Name Alternative
Kalamycin; U-19718
UNSPSC
12352005
Target
Antibiotic; Bacterial; Beta-lactamase; Fungal
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C1C2=C([C@H](O[C@@](C3)([H])[C@]2([H])OC3=O)C)C(C4=C(O)C=CC=C14)=O
Molecular Formula
C16H12O6
Molecular Weight
300.26
References & Citations
[1]Jabila Mary TR, et al. β-lactamase inhibitory potential of kalafungin from marine Streptomyces in Staphylococcus aureus infected zebrafish. Microbiol Res. 2021 Mar;244:126666. |[2]Johnson LE, et al. Kalafungin, a new antibiotic produced by Streptomyces tanashiensis strain Kala. Appl Microbiol. 1968 Dec;16 (12) :1815-21.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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