Duazomycin (sodium)

Duazomycin (Duazomycin A) sodium is a glutamine antagonist. Duazomycin sodium can significantly enhance the effectiveness of 6-Mercaptopurine (6-MP) (HY-13677) in experimental allergic encephalomyelitis (EAE) without increasing toxicity[1][2].

Product Specifications

CAS Number

[2839447-07-1]

Product Name Alternative

Duazomycin A (sodium)

UNSPSC

12352211

Target

Glutaminase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Purity

99.11

Solubility

H2O : 50 mg/mL

Smiles

[N-]=[N+]=CC(CC[C@@H](C(O[Na])=O)NC(C)=O)=O

Molecular Formula

C8H10N3NaO4

Molecular Weight

235.17

References & Citations

[1]Vogel C L, et al. Enhanced suppression of experimental allergic encephalomyelitis by combination chemotherapy with duazomycin-A and 6-mercaptopurine[J]. Proceedings of the Society for Experimental Biology and Medicine, 1969, 131 (1) : 251-256.|[2]Rosenberg S, et al. Enhanced Suppression of the Secondary Immune Response by Combination of 6-Mercaptopurine ‘Duazomycin A’[J]. Nature, 1963, 199 (4898) : 1101-1102.