Nevirapine-d8

Nevirapine-d8 (BI-RG 587-d8) is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM[1].

Product Specifications

CAS Number

[1051418-86-0]

Product Name Alternative

BI-RG 587-d8; NSC 641530-d8; NVP-d8

UNSPSC

12352005

Target

HIV; Isotope-Labeled Compounds; Parasite; Reverse Transcriptase

Related Pathways

Anti-infection; Others

Applications

COVID-19-anti-virus

Field of Research

Infection; Cancer

Smiles

O=C1C2=C([2H])C([2H])=C([2H])N=C2N(C3CC3)C4=NC([2H])=C([2H])C(C([2H])([2H])[2H])=C4N1

Molecular Formula

C15H6D8N4O

Molecular Weight

274.35

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Erickson DA, et al. Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitornevirapine by human hepatic cytochromes P-450. Drug Metab Dispos. 1999 Dec;27 (12) :1488-95.|[3]Dong JJ, et al. In vitro evaluation of the therapeutic potential of nevirapine in treatment of human thyroid anaplastic carcinoma. Mol Cell Endocrinol. 2013 May 6;370 (1-2) :113-8.|[4]Merluzzi VJ, et al. Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor. Science. 1990 Dec 7;250 (4986) :1411-3.|[5]Riska PS, et al. Biotransformation of nevirapine, a non-nucleoside HIV-1 reverse transcriptase inhibitor, in mice, rats, rabbits, dogs, monkeys, and chimpanzees. Drug Metab Dispos. 1999 Dec;27 (12) :1434-47.|[6]Onasanwo SA, et al. Evaluation of anti-ulcerogenic and ulcer-healing activities of nevirapine in rats. Afr J Med Med Sci. 2015 Sep;44 (3) :251-9.