Metallibure

Methallibure (ICI 33828) is a dithiocarbamoylhydrazine derivative and gonadotropic function blocker. Methallibure can block the action of pituitary gonadotropins in teleost fishes and inhibit germ cell maturation. Methallibure does not affect the histological structure of the thyroid gland but reduces the nuclear volume of thyroid epithelial cells. Methallibure can be used in the research of endocrine diseases[1][2].

Product Specifications

CAS Number

[926-93-2]

Product Name Alternative

ICI 33828; Methallibure

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Drug Derivative; GnRH Receptor

Related Pathways

GPCR/G Protein; Others

Field of Research

Endocrinology

Purity

90.000000

Smiles

CNC(NNC(NC(C=C)C)=S)=S

Molecular Formula

C7H14N4S2

Molecular Weight

218.34

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Hoar W S, et al. Inhibition of the pituitary gonadotropic activity of fishes by a dithiocarbamoylhydrazine derivative (ICI 33,828) . General and Comparative Endocrinology, 1967, 8 (1) : 101-109.|[2]Löw O, et al. Morphometrie an indokrinen Organen. II. Karyometrie an Schilddrüsen von Hunden und Schweinen nach Applikation von TURISYNCHRON und SUISYNCHRON [Morphometry of endocrine organs. 2. Karyometry of dog and swine thyroid glands following administration of TURISYNCHRON and SUISYNCHRON]. Arch Exp Veterinarmed. 1974;28 (5) :725-30. German.