Ketanserin (tartrate) (Standard)

Ketanserin (tartrate) (Standard) is the analytical standard of Ketanserin (tartrate) . This product is intended for research and analytical applications. Ketanserin (R41468) tartrate is a selective 5-HT2 receptor antagonist. Ketanserin tartrate also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM) .

Product Specifications

CAS Number

[83846-83-7]

Product Name Alternative

R41468 tartrate (Standard)

UNSPSC

12352005

Target

5-HT Receptor; Autophagy; Potassium Channel; Reference Standards

Related Pathways

Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

O=C(C1=CC=CC=C1N2)N(CCN3CCC(C(C4=CC=C(F)C=C4)=O)CC3)C2=O.O=C(O)[C@H](O)[C@@H](O)C(O)=O

Molecular Formula

C26H28FN3O9

Molecular Weight

545.51

References & Citations

[1]Tang Q, et al. The 5-HT2 antagonist Ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels. Br J Pharmacol. 2008 Oct;155 (3) :365-73.|[2]Khan N, et al. Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists. Drug Des Devel Ther. 2015 Jul 6;9:3497-506.|[3]Kekewska A, et al. Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012 Feb;340 (2) :369-76.|[4]Jiang DG, et al. Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress. Neural Regen Res. 2016 Sep;11 (9) :1471-1479.