Populin

Populin (Populoside) is a phenolic glucoside with antioxidant activities. Populin inhibits aldose reductase with an IC50 of 18.55 μM. Populin shows IC50s of 6.76 µM and 1.69 mM in DPPH radical-scavenging and ABTS ·+ radical-scavenging assays. Populin also inhibits D-Sorbitol (HY-B0400) accumulation.Populin has the potential to be used in the study of diabetic complications[1][2].

Product Specifications

CAS Number

[99-17-2]

Product Name Alternative

Populoside; Salicin 6-benzoate; NSC 128308

UNSPSC

12352005

Target

Aldose Reductase

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Smiles

O=C(C1=CC=CC=C1)OC[C@H]([C@H]([C@@H]([C@H]2O)O)O)O[C@H]2OC3=C(C=CC=C3)CO

Molecular Formula

C20H22O8

Molecular Weight

390.38

References & Citations

[1]Si CL, et al. Phenolic compounds in the leaves of Populus ussuriensis and their antioxidant activities. Planta Med. 2009 Aug;75 (10) :1165-7. |[2]Lee, Y.S., et al. Inhibitory effect of populoside from the bark of Populus nigra on aldose reductase. J. Korean Soc. Appl. Biol. Chem. 53, 729-733 (2010) .