Trimethylcolchicinic acid

Trimethylcolchicinic acid (Desacetylcolchiceine; N-Deacetylcolchiceine) is a colchicine analogue. Trimethylcolchicinic acid promotes the production of chondroitin sulfate in L cells and inhibits the production of dermatan sulfate. Trimethylcolchicinic acid reduces liver fibrosis and cholestasis induced by long-term biliary obstruction in rats. Trimethylcolchicinic acid has potential for use in research on diseases such as liver fibrosis, gout, and cancer[1][2][3].

Product Specifications

CAS Number

[3482-37-9]

Product Name Alternative

Desacetylcolchiceine; N-Deacetylcolchiceine

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Others

Related Pathways

Others

Field of Research

Cancer; Metabolic Disease

Smiles

COC1=C2C(C([C@H](CCC2=CC(OC)=C1OC)N)=C3)=CC=C(O)C3=O

Molecular Formula

C19H21NO5

Molecular Weight

343.37

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

References & Citations

[1]Lorans G, et al. Effect of trimethylcolchicinic acid on the synthesis and excretion of proteoglycans in tissue culture. Eur J Biochem. 1975 Jan 15;50 (3) :563-9. |[2]Muriel P, et al. Trimethylcolchicinic acid decreases liver fibrosis and cholestasis induced by prolonged biliary obstruction in the rat. J Appl Toxicol. 1997 May-Jun;17 (3) :145-51.|[3]WALLACE SL. Trimethylcolchicinic acid in the treatment of acute gout. Ann Intern Med. 1961 Feb;54:274-9.