ORG-20241
ORG-20241 is a PDE3/PDE4 dual inhibitor. ORG-20241 has a significant bronchodilator effect and completely prevents allergen induced airway hyperresponsiveness. ORG-20241 can significantly inhibit eosinophil infiltration at high concentrations. ORG-20241 can be used for research on asthma[1].
Product Specifications
CAS Number
145261-31-0
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
ONC(C1=NC(C2=CC(OC)=C(OC)C=C2)=CS1)=N
Molecular Formula
C12H13N3O3S
Molecular Weight
279.31
References & Citations
[1]Santing RE, et al. Bronchodilatory and anti-inflammatory properties of inhaled selective phosphodiesterase inhibitors in a guinea pig model of allergic asthma. Eur J Pharmacol. 2001 Oct 19;429 (1-3) :335-44.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE3; PDE4
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