MDL 27032
MDL 27032 is an active site-directed inhibitor of protein kinase C (PKC) and cAMP-dependent protein kinase (PKA) with Ki values of 24 and 14.3μM. MDL 27032 can relaxe vascular smooth muscle and can be used as vasodilator[1].
Product Specifications
CAS Number
[110124-55-5]
UNSPSC
12352005
Target
PKA; PKC
Related Pathways
Epigenetics; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cardiovascular Disease
Smiles
CCCC(N1)=C(C2=CC=NC=C2)OC1=O
Molecular Formula
C11H12N2O2
Molecular Weight
204.23
References & Citations
[1]Robinson P J, et al. MDL 27,032 [4-propyl-5- (4-pyridinyl) -2 (3H) -oxazolone], an active site-directed inhibitor of protein kinase C and cyclic AMP-dependent protein kinase that relaxes vascular smooth muscle[J]. The Journal of pharmacology and experimental therapeutics, 1990, 255 (3) : 1392-1398.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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