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Tariquidar (methanesulfonate, hydrate) (Standard)

Tariquidar (methanesulfonate, hydrate) (Standard) is the analytical standard of Tariquidar (methanesulfonate, hydrate) . This product is intended for research and analytical applications. Tariquidar methanesulfonate, hydrate (XR9576 methanesulfonate, hydrate) is a potent and specific inhibitor of P-glycoprotein (P-gp) with a Kd of 5.1 nM.

Product Specifications

CAS Number

[625375-83-9]

Product Name Alternative

XR9576 (methanesulfonate, hydrate) (Standard)

UNSPSC

12352005

Target

P-glycoprotein; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Cancer

Smiles

O=C(C1=CC2=CC=CC=C2N=C1)NC3=CC(OC)=C(OC)C=C3C(NC4=CC=C(CCN5CC6=C(C=C(OC)C(OC)=C6)CC5)C=C4)=O.CS(=O)(O)=O.CS(=O)(O)=O.O.O.O

Molecular Formula

C40H52N4O15S2

Molecular Weight

892.99

References & Citations

[1]Martin C, et al. The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein. Br J Pharmacol, 1999, 128 (2), 403-411.|[2]Mistry P, et al. In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576. Cancer Res, 2001, 61 (2), 749-758.|[3]Vraka C, et al. A new method measuring the interaction of radiotracers with the human P-glycoprotein (P-gp) transporter. Nucl Med Biol. 2018 Feb 14;60:29-36.

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-10550AR/

Scientific Category

Reference Standards

Available Sizes

Curated Selection

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