EXP-7711
EXP-7711 is a non peptide angiotensin II (Ang II) AT1 receptor antagonist. EXP-7711’s affinity for wild-type AT1 receptor (Ki =180 nM) is lower than peptide antagonists, but higher than losartan (Ki = 12 nM) . EXP-7711 can be used for research on cardiovascular conditions[1].
Product Specifications
CAS Number
[114798-27-5]
UNSPSC
12352005
Target
Angiotensin Receptor
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Smiles
CCCCC1=NC(Cl)=C(CO)N1CC2=CC=C(C3=C(C=CC=C3)C(O)=O)C=C2
Molecular Formula
C22H23ClN2O3
Molecular Weight
398.88
References & Citations
[1]Noda K, et al. Tetrazole and carboxylate groups of angiotensin receptor antagonists bind to the same subsite by different mechanisms. J Biol Chem. 1995 Feb 3;270 (5) :2284-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AT1 Receptor
Curated Selection
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