CI-986
CI-986 is a dual inhibitor of COX and 5-LOX. CI-986 can prevent the coronary vasoconstriction and the increased production of LTB (4) and LTC (4) . CI-986 also has anti-inflammatory and analgesic effects. CI-986 can be used for the researches of inflammation and cardiovascular disease, such as arthritis[1][2].
Product Specifications
CAS Number
130116-16-4
UNSPSC
12352005
Target
COX; Lipoxygenase
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Smiles
[O-]C1=C(C(C)(C)C)C=C(C2=NNC(S2)=S)C=C1C(C)(C)C.OCC[N+](C)(C)C
Molecular Formula
C21H35N3O2S2
Molecular Weight
425.65
References & Citations
[1]Gök S, et al. Role of leukotrienes on coronary vasoconstriction in isolated hearts of arthritic rats: effect of in vivo treatment with CI-986, a dual inhibitor of cyclooxygenase and lipoxygenase. Pharmacology. 2000 Jan;60 (1) :41-6.|[2]Schrier DJ, et al. The pharmacologic effects of 5-[3,5-bis (1,1-dimethylethyl) -4- hydroxyphenyl]-1,3,4-thiadiazole-2 (3H) -thione, choline salt (CI-986), a novel inhibitor of arachidonic acid metabolism in models of inflammation, analgesia and gastric irritation. Prostaglandins. 1994 Jan;47 (1) :17-30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-LOX
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