NCX-530
NCX-530 is an Indomethacin molecule chemically conjugated with a NO moiety. NCX-530 can release NO. NCX-530 can inhibit cancer cells proliferation and induce apoptosis. NCX-530 can be used for the researches of cancer and inflammation[1][2].
Product Specifications
CAS Number
204268-63-3
UNSPSC
12352005
Target
Apoptosis
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(C1=CC=C(Cl)C=C1)N2C3=C(C=C(OC)C=C3)C(CC(OC4=CC(CO[N+]([O-])=O)=CC=C4)=O)=C2C
Molecular Formula
C26H21ClN2O7
Molecular Weight
508.91
References & Citations
[1]Ragot T, et al. Apoptosis induction by combination of drugs or a conjugated molecule associating non-steroidal anti-inflammatory and nitric oxide donor effects in medullary thyroid cancer models: implication of the tumor suppressor p73. Thyroid Res. 2015 Aug 14;8:13.|[2]Takeuchi K, et al. Lack of gastric toxicity of nitric oxide-releasing indomethacin, NCX-530, in experimental animals. Dig Dis Sci. 2001 Aug;46 (8) :1805-18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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