KB R6933

KB R6933 (KB 6806 maleate) is a potent, selective and orally active 5-HT3 receptor antagonist. KB R6933 can inhibit the diarrhea induced by 5-HT (HY-B1473A), but not that by Castor Oil (HY-107799) or prostaglandin E2 (PGE2) (HY-101952) . KB R6933 can inhibit 5-HT-induced bradycardia[1][2].

Product Specifications

CAS Number

[148565-09-7]

Product Name Alternative

KB 6806 (maleate)

UNSPSC

12352005

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

OC(/C=C\C(O)=O)=O.CC(N1C(N2CCN(CC2)C)=NC3=CC(Cl)=C(N)C=C31)C.OC(/C=C\C(O)=O)=O

Molecular Formula

C23H30ClN5O8

Molecular Weight

539.97

References & Citations

[1]Ozaki A, et al. Effect of the 5-hydroxytryptamine3 (5-HT3) -receptor antagonist KB-R6933 on experimental diarrhea models. Jpn J Pharmacol. 1999 May;80 (1) :93-6.