KB R6933
KB R6933 (KB 6806 maleate) is a potent, selective and orally active 5-HT3 receptor antagonist. KB R6933 can inhibit the diarrhea induced by 5-HT (HY-B1473A), but not that by Castor Oil (HY-107799) or prostaglandin E2 (PGE2) (HY-101952) . KB R6933 can inhibit 5-HT-induced bradycardia[1][2].
Product Specifications
CAS Number
[148565-09-7]
Product Name Alternative
KB 6806 (maleate)
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
OC(/C=C\C(O)=O)=O.CC(N1C(N2CCN(CC2)C)=NC3=CC(Cl)=C(N)C=C31)C.OC(/C=C\C(O)=O)=O
Molecular Formula
C23H30ClN5O8
Molecular Weight
539.97
References & Citations
[1]Ozaki A, et al. Effect of the 5-hydroxytryptamine3 (5-HT3) -receptor antagonist KB-R6933 on experimental diarrhea models. Jpn J Pharmacol. 1999 May;80 (1) :93-6.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-105449A/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT3 Receptor
Curated Selection
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