L-703717
L-703717 is a NMDA receptor antagonist. L-703717 preferentially binds to cerebellar-specific NMDA receptors consisting of a GluRepsilon3 subunit and eventually accumulates in rodent cerebellum. L-703717 can be used for the research of neurological disease[1].
Product Specifications
CAS Number
[142326-92-9]
UNSPSC
12352005
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
OC1=C(C2=CC(CC3=CC=C(OC)C=C3)=CC=C2)C(NC4=CC(Cl)=CC=C14)=O
Molecular Formula
C23H18ClNO3
Molecular Weight
391.85
References & Citations
[1]Haradahira T, et al. Effects of endogenous agonists, glycine and D-serine, on in vivo specific binding of [11C]L-703,717, a PET radioligand for the glycine-binding site of NMDA receptors. Synapse. 2003 Nov;50 (2) :130-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Curated Selection
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