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L-703717

L-703717 is a NMDA receptor antagonist. L-703717 preferentially binds to cerebellar-specific NMDA receptors consisting of a GluRepsilon3 subunit and eventually accumulates in rodent cerebellum. L-703717 can be used for the research of neurological disease[1].

Product Specifications

CAS Number

142326-92-9

UNSPSC

12352005

Target

IGluR

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

OC1=C(C2=CC(CC3=CC=C(OC)C=C3)=CC=C2)C(NC4=CC(Cl)=CC=C14)=O

Molecular Formula

C23H18ClNO3

Molecular Weight

391.85

References & Citations

[1]Haradahira T, et al. Effects of endogenous agonists, glycine and D-serine, on in vivo specific binding of [11C]L-703,717, a PET radioligand for the glycine-binding site of NMDA receptors. Synapse. 2003 Nov;50 (2) :130-6.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NMDA Receptor

Frequently Asked Questions

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