T 162559

T 162559 is a potent and selective inhibitor of the Na+/H+ exchanger isoform NHE1 with IC50 values of 0.96 nM. T 162559 does not affect Na+/HCO3- cotransport and Na+/Ca2+ exchange. T 162559 can be used for the research of cardiovascular disease[1].

Product Specifications

CAS Number

[339532-12-6]

UNSPSC

12352005

Target

Na+/H+ Exchanger (NHE)

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

CS(=O)(O)=O.CS(=O)(O)=O.CC1=C([C@@H]2C/C(C3=C(C)C=CN=C3C2)=N\NC(N)=N)C=C(F)C=C1

Molecular Formula

C20H28FN5O6S2

Molecular Weight

517.59

References & Citations

[1]Kawamoto T, et al. Potent and selective inhibition of the human Na+/H+ exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559. Eur J Pharmacol. 2001 May 18;420 (1) :1-8.|[2]Kusumoto K, et al. In vitro and in vivo pharmacology of a structurally novel Na+-H+ exchange inhibitor, T-162559. Br J Pharmacol. 2002 Apr;135 (8) :1995-2003.