L 373890
L 373890 is a selective pyridinone acetamide thrombin inhibitor with a Ki of 0.5 nM. L 373890 shows highly selectivity for thrombin over trypsin (Ki of 570 nM), serine proteases plasmin, tPA, activated protein C, plasma kallikrein and chymotrypsin. L 373890 can be used for thrombosis research[1].
Product Specifications
CAS Number
[187162-33-0]
UNSPSC
12352005
Target
Thrombin
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=S(NC1=CC=C(C)N(CC(NCC2CCN(C(N)=N)CC2)=O)C1=O)(CC3=CC=CC=C3)=O
Molecular Formula
C22H30N6O4S
Molecular Weight
474.58
References & Citations
[1]Philip E.J. Sanderson, et al. L-373,890, An achiral, noncovalent, subnanomolar thrombin inhibitor. Bioorganic & Medicinal Chemistry Letters. Volume 7, Issue 12, 17 June 1997, Pages 1497-1500.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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